AHCC supplement shows potential in protecting the liver from fibrosis
His research team investigated how AHCC (Amino Up Co., Ltd., Sapporo, Japan), a standardized extract of cultured Lentinula edodes mycelia, protects the liver and its mechanism.
The team administered AHCC to mice and found that the supplement might inhibit the activation of hepatic stellate cells through two channels.
Via the TLR2 (toll-like receptor protein) channel, AHCC induced cytoglobin that decreased reactive oxygen species, while via the TLR4 channel, the supplement suppressed the expression of collagen in the liver of the mice.
"We aim to conduct clinical trials to confirm the efficacy of AHCC in patients with liver fibrosis to build more reliable scientific evidence," Dr. Urushima stated.
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